Applying solitary-molecule optical and AFM imaging and power-spectroscopy techniques, we request to unravel the mechanistic areas of the construction and dynamics of chromosomes. Our study interests involve:
Human Rad51 filaments on double- and single-stranded DNA: correlating typical and irregular sorts with recombination perform.
Again in 1991, Sumio Iijima of the NEC Company had reported the synthesis of carbon nanotubes. Band construction calculations recommended that these nanotubes could exhibit metallic band conduction. This could be a substantial benefit above the conducting polymers we had explored, which had been, actually, disordered semiconductors providing simply variable-variety hopping conductivity.
Because 2000, Dekker has shifted the leading focus of his perform to biophysics exactly where he reports the Attributes of single biomolecules and cells using the equipment of nanotechnology. This modification of field was driven by his fascination to the amazing performing of Organic molecular structures, and also because of the long-term viewpoint that lots of appealing discoveries is usually expected Within this area.[5] Existing traces of exploration in his biophysics team are from the parts of:[six]
This yielded a breakthrough. Inside of only some months, we have been capable of evaluate transport by a person one-walled carbon nanotube. According to small-temperature experiments by an excellent PhD university student in my group, Sander Tans (now a valued colleague and professor at Delft College of Technologies by having an active exploration lab at AMOLF in Amsterdam), we showed that carbon nanotubes have been legitimate quantum wires with extremely very long (micrometres) electronic coherence lengths — confirming theoretical predictions of metallic behaviour.
Our research ranges in the biophysics of DNA to synthetic cells and beyond. Please take a look down below within the spectrum of our present-day jobs.
We shape germs into forms that deviate from their natural phenotype. Specifically, I'll exhibit our capacity to shape live E. coli microbes into novel styles for example rectangles, squares, triangles and circles.
2000, discovery that nanotubes can have incredible big latest densities; fixed the controversial concern of Digital transportation through DNA molecules by measurements of insulating conduct at The only molecule amount; and demonstration of an AFM method for solitary-molecule manipulation of nanotubes
This "Cited by" count consists of citations to the next articles or blog posts in Scholar. Those marked * may very well be different in the write-up inside the profile.
‘The fantastically refined way where factors in character perform by no means ceases to amaze me. If we solve the puzzle of how lifetime came into becoming, I expect that my amazement within the complexity of development can have increased and with it my awe with the greatness on the Creator.’
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1999, to start with measurement in the wavefunction of one molecular orbitals of carbon nanotubes; and discovery of kink heterojunctions of carbon nanotubes which gave decisive evidence for your new Luttinger ceesdekker.net description of interacting electrons in nanotubes
Visualization of unstained DNA nanostructures with Sophisticated in-emphasis transmission electron microscopy approaches
Supercoiling-dependent DNA binding: quantitative modeling and purposes to bulk and one-molecule experiments